20 juillet 2014

Les gencives d'Ötzi

Ötzi, le célèbre homme préhistorique découvert dans les Alpes près de la frontière entre l'Italie et l'Autriche, avait de sérieux problème de gencives. Les bactéries qui attaquaient ses gencives s'étaient répandues jusqu'à son os pelvien! C'est un puissant rappel des souffrances que devaient subir nos ancêtres, privés de la médecine moderne!

Extrait de la découverte:

A couple years ago, Ötzi’s genome was sequenced using a pelvic bone sample weighing just 0.1 grams. From this, we know that he was lactose intolerant and had type-O blood. Non-hominoid sequences were also detected with the mummified remains. These non-human reads are referred to as his “metagenome,” and it indicates the presence of microbes. 

Now, a team led by Frank Maixner of EURAC Research in Italy reanalyzed the metagenomic data of the Iceman’s genomic survey (pictured below). They found evidence of a pathogen in the tissue biopsy. Called Treponema denticola, this opportunistic oral pathogen is involved in the development of periodontal (or gum) disease. Its sizeable presence was especially surprising: The pathogen had to have been distributed via the bloodstream from the mouth to the hip bone.

“This ‘non-human’ DNA mostly derives from bacteria normally living on and within our body. Only the interplay between certain bacteria or an imbalance within this bacterial community might cause certain diseases,” study coauthor Thomas Rattei from the University of Vienna explains in a news release “It is highly important to reconstruct and understand the bacterial community composition by analyzing this DNA mixture.” 

According to the researchers, the bacteria didn’t colonize the body after death; they were part of Ötzi’s “commensal oral microflora” when he was alive. These findings confirm a CT-based diagnosis published last year showing that the Iceman suffered from periodontitis, an infection of the ligaments and bones that support teeth. It’s what happens when inflamed gums go unchecked.

The pathogen’s presence was further confirmed when the team analyzed gum tissue biopsy and a mouth swab sample taken from the Iceman. The work was published in PLoS ONE last month. 

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